Orphanet: Ichthyosis hystrix of Curth Macklin

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Ichthyosis hystrix of Curth-Macklin

Disease definition

Ichthyosis hystrix of Curth-Macklin (IHCM) is a rare type of keratinopathic ichthyosis (see this term) that is characterized by the presence of severe hyperkeratotic lesions and palmoplantar keratoderma (PPK, see this term).


Classification level: Disorder
  • Synonym(s):
    • Ichthyosis hystrix, Curth-Macklin type
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal dominant or Not applicable 
  • Age of onset: Childhood
  • ICD-10: Q80.8
  • OMIM: 146590
  • UMLS: C0432307  C1840296
  • MeSH: C536088
  • GARD: 2954
  • MedDRA: -

Detailed information


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