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Heavy chain disease

Disease definition

Heavy-chain diseases (HCDs) are rare monoclonal lymphoplasma-cell proliferative disorders involving B cells and are characterized by the synthesis of truncated heavy chains without associated light chains.


  • Synonym(s):
    • HCD
  • Prevalence: Unknown
  • Inheritance: -
  • Age of onset: Adult
  • ICD-10: C88.2  C88.3
  • OMIM: -
  • UMLS: C0018852
  • MeSH: D006362
  • GARD: -
  • MedDRA: 10019350

Detailed information


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