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Methotrexate-associated lymphoproliferative disorders

Disease definition

Methotrexate-associated lymphoproliferative disorders are rare immunodeficiency-associated lymphoproliferative diseases characterized by lymphoid proliferation or lymphomas (large B-cell lymphoma, T-cell lymphoma, Hodgkin lymphoma, reactive lymphadenitis and a polymorphic post-transplant lymphoproliferative disorder) that develop in patients with different autoimmune diseases treated with methotrexate. Swelling is the predominant manifestation of the disease and regression after methotrexate withdrawal is observed in a significant proportion of patients.


Classification level: Disorder
  • Synonym(s):
    • MTX-LPD
    • MTX-associated lymphoproliferative disorders
  • Prevalence: -
  • Inheritance: -
  • Age of onset: -
  • ICD-10: D47.7
  • OMIM: -
  • UMLS: -
  • MeSH: -
  • GARD: -
  • MedDRA: -

Additional information

Further information on this disease

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