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Wells syndrome is characterised by the presence of recurrent cellulitis-like eruptions with eosinophilia.
ORPHA:901Classification level: Disorder
- Eosinophilic cellulitis
- Prevalence: <1 / 1 000 000
- Inheritance: Not applicable
- Age of onset: Adult
- ICD-10: L98.3
- OMIM: -
- UMLS: C0343101
- MeSH: C536693
- GARD: 329
- MedDRA: -
Approximately 80 cases have been described in the literature.
The lesions are usually filled with fluid, tender and progress to form hardened plaques of edema and erythema. They usually resolve without scarring.
Histological studies reveal flame figures and heavy infiltration of eosinophils and histiocytes.
The syndrome is usually sporadic but familial cases have been reported.