Orphanet: ALys amyloidosis
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ALys amyloidosis

Disease definition

A rare, hereditary amyloidosis with primary renal involvement characterized by amyloid deposition in the kidney glomeruli and medulla, gastrointestinal tract, liver, spleen and slow disease progression. Symptoms and signs include nausea, vomiting, dyspepsia, gastritis, gastrointestinal hemorrhage, abdominal pain, hepatic rupture, sicca syndrome, purpura and petechiae, lymphadenopathy and renal dysfunction.

ORPHA:93561

Classification level: Subtype of disorder
  • Synonym(s):
    • Familial amyloid nephropathy due to lysozyme variant
    • Familial renal amyloidosis due to lysozyme variant
    • Hereditary amyloid nephropathy due to lysozyme variant
    • Hereditary renal amyloidosis due to lysozyme variant
    • Lysozyme amyloidosis
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal dominant 
  • Age of onset: -
  • ICD-10: E85.0
  • OMIM: -
  • UMLS: -
  • MeSH: -
  • GARD: -
  • MedDRA: -

  A summary on this disease is available in Español (2018) Italiano (2018) Nederlands (2018)

Detailed information

General public

ERN : produced/endorsed by ERN(s)
FSMR : produced/endorsed by FSMR(s)

Additional information

Further information on this disease

Patient-centred resources for this disease

Research activities on this disease

Specialised Social Services

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