Orphanet: ALys amyloidosis

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ALys amyloidosis

Disease definition

A rare, hereditary amyloidosis with primary renal involvement characterized by amyloid deposition in the kidney glomeruli and medulla, gastrointestinal tract, liver, spleen and slow disease progression. Symptoms and signs include nausea, vomiting, dyspepsia, gastritis, gastrointestinal hemorrhage, abdominal pain, hepatic rupture, sicca syndrome, purpura and petechiae, lymphadenopathy and renal dysfunction.


Classification level: Subtype of disorder
  • Synonym(s):
    • Familial amyloid nephropathy due to lysozyme variant
    • Familial renal amyloidosis due to lysozyme variant
    • Hereditary amyloid nephropathy due to lysozyme variant
    • Hereditary renal amyloidosis due to lysozyme variant
    • Lysozyme amyloidosis
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal dominant 
  • Age of onset: -
  • ICD-10: E85.0
  • OMIM: -
  • UMLS: -
  • MeSH: -
  • GARD: -
  • MedDRA: -

Detailed information

Article for general public

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