Orphanet: Nephrogenic syndrome of inappropriate antidiuresis

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Nephrogenic syndrome of inappropriate antidiuresis

Disease definition

Nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is a rare genetic disorder of water balance, closely resembling the far more frequent syndrome of inappropriate antidiuretic secretion (SIAD), and characterized by euvolemic hypotonic hyponatremia due to impaired free water excretion and undetectable or low plasma arginine vasopressin (AVP) levels.


Classification level: Disorder
  • Synonym(s):
    • NSIAD
  • Prevalence: <1 / 1 000 000
  • Inheritance: X-linked recessive 
  • Age of onset: Childhood
  • ICD-10: E22.2
  • OMIM: 300539
  • UMLS: C1845202
  • MeSH: -
  • GARD: -
  • MedDRA: -

Detailed information


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