Search for a rare disease

* (*) mandatory field

Other search option(s)

Suggest an update

(*) Required fields.


Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed.

Captcha image

Multicentric Castleman disease

Disease definition

Multicentric castleman disease (MCD) is an aggressive form of Castleman disease (see this term) that mostly results from human herpesvirus 8 (HHV8) infection. It manifests by fever, diffuse lymphadenopathy, hepatosplenomegaly, Involvement of the respiratory system and increased C-reactive protein.


Classification level: Subtype of disorder
  • Synonym(s):
    • MCD
    • Multicentric giant lymph node hyperplasia
  • Prevalence: -
  • Inheritance: -
  • Age of onset: -
  • ICD-10: D36.0
  • OMIM: 148000
  • UMLS: C1334815
  • MeSH: C537372
  • GARD: 9644
  • MedDRA: -

Additional information

Further information on this disease

Specialised Social Services

The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.