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Caribbean parkinsonism
Disease definition
Parkinsonism with dementia of Guadeloupe is characterised by symmetrical bradykinesia, predominantly axial rigidity, postural instability with early falls and cognitive decline with prominent features of frontal lobe dysfunction.
ORPHA:97355
Classification level: Disorder- Synonym(s):
- Atypical parkinsonism in the Caribbean
- Prevalence: Unknown
- Inheritance: -
- Age of onset: Adult, Elderly
- ICD-10: F02.3* G20+
- OMIM: -
- UMLS: -
- MeSH: -
- GARD: -
- MedDRA: -
Summary
Epidemiology
Prevalence is unknown, but a higher number of cases have been described in the French West Indies.
Etiology
This form of atypical parkinsonism may be related to exposure to tropical plants containing mitochondrial complex I inhibitors.
Differential diagnosis
Guadelupian parkinsonism may actually be a tauopathy identical or closely related to progressive supranuclear palsy (see this term).
Management and treatment
Most patients are L-dopa unresponsive.
Additional information
Further information on this disease
Patient-centred resources for this disease
Research activities on this disease
Specialised Social Services
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