Orphanet: Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)

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Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)

Disease definition

A rare acute myeloid leukemia (AML) with recurrent genetic anomaly disorder characterized by an inv(16)(p13q22) or t(16;16)(p13;q22) cytogenic abnormality, which generates a CBFB-MYH11 fusion gene, presenting with typical morphologic features of AML as well as abnormal bone marrow eosinophils (seen in all stages of maturation with no significant signs of maturation arrest). Myeloid sarcoma and involvement of the central nervous system is relatively common. Cytology reveals myeloblasts, a significant monocytic component and variable numbers of immature eosinophils with atypical purple-violet granules in addition to eosinophilic granules. Presence of the fusion gene is sufficent for diagnosis irrespective of blast count.

ORPHA:98829

Classification level: Disorder

Synonym(s):
- AML with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)
Prevalence: -
Inheritance: -
Age of onset: -
ICD-10: C92.5
ICD-11: 2A60.0
OMIM: -
UMLS: C5395080
MeSH: -
GARD: 536
MedDRA: -

Detailed information

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Article for general public
Deutsch (2022) - Onkopedia

Guidelines

Clinical practice guidelines
Français (2011) - ALD
English (2017) - Blood

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Review article
Deutsch (2017) - Onkopedia

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English (2023) - PROQOLID^TM

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Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)

ORPHA:98829

A summary on this disease is available in Deutsch (2019) Español (2019) Français (2019) Italiano (2019) Nederlands (2019)

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Guidelines

Disease review articles

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