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Acute myeloblastic leukemia without maturation

Disease definition

A rare, acute myeloid leukemia characterized by no significant myeloid maturation and more than 90% blast cells in the non-erythroid population. Various degrees of anemia, thrombocytopenia, or pancytopenia are present. Frequent clinical manifestations include fatigue, fever, bleeding disorders, and organomegaly, especially hepatosplenomegaly.

ORPHA:98833

Classification level: Disorder
  • Synonym(s):
    • AML M1
    • Acute myeloblastic leukemia M1
  • Prevalence: -
  • Inheritance: Not applicable 
  • Age of onset: Adult
  • ICD-10: C92.0
  • OMIM: -
  • UMLS: C0026998
  • MeSH: -
  • GARD: 526
  • MedDRA: -

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