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Autosomal dominant spastic paraplegia type 8
Disease definition
A rare, pure or complex form of hereditary spastic paraplegia characterized by early adulthood onset of slowly progressive lower limb spasticity resulting in gait disturbances, hyperreflexia and extensor plantar responses, urinary urgency and/or incontinence, muscle weakness, decreased vibration sense and mild muscular atrophy in lower extremities. It may be associated with complicating signs, such as sensory neuropathy, ataxia (i.e. mild dysmetria, uncoordinated eye movement) and mild dysphagia.
ORPHA:100989
Classification level: DisorderA summary on this disease is available in Deutsch (2021) Español (2021) Français (2021) Nederlands (2021) Português (2021) Italiano (2019)
Detailed information
General public
- Article for general public
- Français (2015, pdf) - Fondation Groupama
- Svenska (2020) - Socialstyrelsen
Disease review articles
- Clinical genetics review
- English (2020) - GeneReviews
- English (2021) - GeneReviews
Disability
- Disability factsheet
- Français (2018, pdf) - Orphanet


Additional information
Further information on this disease
Patient-centred resources for this disease
Research activities on this disease
Specialised Social Services
The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.