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APC - APC regulator of WNT signaling pathway
- Synonym(s) : DP2, DP2.5, DP3, PPP1R46, protein phosphatase 1, regulatory subunit 46
- Previous symbols and names : APC, WNT signaling pathway regulator, adenomatosis polyposis coli, adenomatous polyposis coli
- Type : gene with protein product
- Chromosomal location : 5q22.2
- OMIM: 611731
- HGNC: 583
- UniProtKB: P25054
- Genatlas: APC
- GenCC: APC
- Ensembl: ENSG00000134982
- IUPHAR-DB: -
- Reactome: P25054
- LOVD: APC
Diseases list
- Disease-causing germline mutation(s) in APC-related attenuated familial adenomatous polyposis
ORPHA:247806 
- Disease-causing germline mutation(s) in Cenani-Lenz syndrome
ORPHA:3258 - Disease-causing germline mutation(s) in Gardner syndrome
ORPHA:79665 - Disease-causing germline mutation(s) in Gastric adenocarcinoma and proximal polyposis of the stomach
ORPHA:314022 - Disease-causing germline mutation(s) in Turcot syndrome with polyposis
ORPHA:99818 - Disease-causing somatic mutation(s) in Desmoid tumor
ORPHA:873 - Role in the phenotype of Familial adenomatous polyposis due to 5q22.2 microdeletion
ORPHA:261584
: AssessedAdditional information
Patient-centred resources for this gene
Research activities on this gene
Specialised Social Services
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