Orphanet: Distal hereditary motor neuropathy, Jerash type

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Distal hereditary motor neuropathy, Jerash type

Disease definition

A rare, genetic, neuromuscular disease characterized by progressive, symmetrical, moderate to severe, distal muscle weakness and atrophy, without sensory involvement, first affecting the lower limbs (towards the end of the first decade) and then involving (within two years) the upper extremities. Patients typically develop foot drop, pes varus, hammer toes and claw hands. Pyramidal tract signs (such as brisk knee reflexes and positive Babinski sign) with absent ankle reflexes are initially associated but regress as disease stabilizes (~10 years after onset).

ORPHA:139552

Classification level: Disorder

Synonym(s):
- Autosomal recessive distal spinal muscular atrophy type 2
- dHMNJ
Prevalence: <1 / 1 000 000
Inheritance: Autosomal recessive
Age of onset: Childhood
ICD-10: G12.2
OMIM: 605726
UMLS: C1854023
MeSH: -
GARD: 10133
MedDRA: -

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Distal hereditary motor neuropathy, Jerash type

ORPHA:139552

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