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Serrated polyposis syndrome

Disease definition

A rare, genetic intestinal disease characterized by the presence of multiple (usually large) hyperplastic/serrated colorectal polyps, usually with a pancolonic distribution. Histology reveals hyperplastic polyps, sessile serrated adenomas (most common), traditional serrated adenomas or mixed polyps. It is associated with an increased personal and familial (first-degree relatives) risk of colorectal cancer.


Classification level: Disorder
  • Synonym(s):
    • Hyperplastic polyposis syndrome
  • Prevalence: 1-5 / 10 000
  • Inheritance: Unknown or Autosomal dominant or Multigenic/multifactorial 
  • Age of onset: Adult, Elderly
  • ICD-10: D12.6
  • OMIM: 617108
  • UMLS: -
  • MeSH: -
  • GARD: -
  • MedDRA: -
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