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Serrated polyposis syndrome

Disease definition

A rare, genetic intestinal disease characterized by the presence of multiple (usually large) hyperplastic/serrated colorectal polyps, usually with a pancolonic distribution. Histology reveals hyperplastic polyps, sessile serrated adenomas (most common), traditional serrated adenomas or mixed polyps. It is associated with an increased personal and familial (first-degree relatives) risk of colorectal cancer.

ORPHA:157798

Classification level: Disorder
  • Synonym(s):
    • Hyperplastic polyposis syndrome
  • Prevalence: 1-5 / 10 000
  • Inheritance: Unknown or Autosomal dominant or Multigenic/multifactorial 
  • Age of onset: Adult, Elderly
  • ICD-10: D12.6
  • OMIM: 617108
  • UMLS: -
  • MeSH: -
  • GARD: -
  • MedDRA: -

  A summary on this disease is available in Deutsch (2017) Español (2017) Français (2017) Italiano (2017) Nederlands (2017)

Additional information

Further information on this disease

Patient-centred resources for this disease

Research activities on this disease

Specialised Social Services

The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.