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Familial advanced sleep-phase syndrome

Disease definition

A rare genetic neurological disorder characterized by very early sleep onset and offset. Plasma melatonin levels and body core temperature rhythms are also phase-advanced. The sleep-wake cycle is generally shortened. Additional reported features include migraine with or without aura and seasonal affective disorder.


Classification level: Disorder
  • Synonym(s):
    • FASPS
  • Prevalence: -
  • Inheritance: Autosomal dominant 
  • Age of onset: Childhood, Adolescent
  • ICD-10: G47.2
  • OMIM: 604348  615224  616882
  • UMLS: C1858496
  • MeSH: -
  • GARD: 9242
  • MedDRA: -
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