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Wolcott-Rallison syndrome

Disease definition

Wolcott-Rallison syndrome (WRS) is a very rare genetic disease, characterized by permanent neonatal diabetes mellitus (PNDM) with multiple epiphyseal dysplasia and other clinical manifestations, including recurrent episodes of acute liver failure.

ORPHA:1667

  • Synonym(s):
    • Early-onset diabetes mellitus with multiple epiphyseal dysplasia
    • WRS
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal recessive 
  • Age of onset: Infancy, Neonatal
  • ICD-10: E13
  • OMIM: 226980
  • UMLS: C0432217
  • MeSH: C536739
  • GARD: 5589
  • MedDRA: -

Detailed information

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