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Male infertility due to globozoospermia

Disease definition

Male infertility due to globozoospermia is a male infertility due to sperm disorder characterized by the presence, in sperm, of a large majority of round-headed spermatozoa that lack the acrosome and have an aberrant nuclear membrane and midpiece defects. The acrosomeless spermatozoa is not able to penetrate the zona pellucida and thus fertilization failures, even with intracytoplasmic sperm injection, are frequent.


Classification level: Subtype of disorder
  • Synonym(s):
    • Male infertility due to round-headed spermatozoa
    • Round-headed sperm syndrome
  • Prevalence: -
  • Inheritance: Autosomal recessive 
  • Age of onset: Adult
  • ICD-10: N46
  • OMIM: 102530  613958
  • UMLS: -
  • MeSH: -
  • GARD: 12502
  • MedDRA: -
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