Search for a rare disease

* (*) mandatory field

Other search option(s)

Suggest an update

(*) Required fields.


Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed.

Orphanet doesn't provide personalised answers. To get in touch with the Orphanet team, please contact

Information provided in your contribution (including your email address) will be stocked in .CSV files that will be sent as an email to Orphanet's teams. These emails might be conserved in the teams' mailboxes, in our backoffice servers but will not be registered in our databases (for more information see our section General Data Protection Regulation and data privacy (GDPR) and Confidentiality).

Captcha image

Primary biliary cholangitis

Disease definition

A rare autoimmune cholestatic liver disease characterized by autoimmune mediated damage of small intrahepatic bile ducts leading to cholestasis, fibrosis, and potential cirrhosis.


Classification level: Disorder
  • Synonym(s):
    • Hanot syndrome
    • PBC
    • Primary biliary cirrhosis
  • Prevalence: 1-5 / 10 000
  • Inheritance: Multigenic/multifactorial or Unknown 
  • Age of onset: Adolescent, Adult, Elderly
  • ICD-10: K74.3
  • OMIM: 109720  613007  613008  614220  614221
  • UMLS: C0008312  C0859942
  • MeSH: -
  • GARD: 7459
  • MedDRA: 10004661  10019137

Detailed information


The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.