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Systemic capillary leak syndrome

Disease definition

Systemic capillary leak syndrome (SCLS) is a severe systemic disease due to increased capillary permeability, characterized by episodes of hypotension, edema and hypovolemia.


  • Synonym(s):
    • Capillary hyperpermeability syndrome
    • Capillary leak syndrome
    • Clarkson disease
    • Idiopathic capillary leak syndrome
    • SCLS
  • Prevalence: <1 / 1 000 000
  • Inheritance: Not applicable 
  • Age of onset: Adult
  • ICD-10: I78.8
  • OMIM: -
  • UMLS: C0343084
  • MeSH: D019559
  • GARD: 1084
  • MedDRA: 10007196

Detailed information


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