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Cleft palate-lateral synechia syndrome

Disease definition

Cleft palate-lateral synechia syndrome (CPLS) is a congenital malformation syndrome characterized by the association of cleft palate and intra-oral lateral synechiae connecting the free borders of the palate and the floor of the mouth. CPLS is presumed to be inherited in an autosomal dominant manner.

ORPHA:2016

Classification level: Disorder
  • Synonym(s):
    • CPLS syndrome
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal dominant 
  • Age of onset: Neonatal, Antenatal
  • ICD-10: Q87.8
  • OMIM: 119550
  • UMLS: C0795898
  • MeSH: -
  • GARD: 1391
  • MedDRA: -
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