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Phacoanaphylactic uveitis

Disease definition

A rare ophthalmic disorder characterized by a zonal granulomatous inflammatory reaction centered around the lens secondary to its traumatic rupture. Signs and symptoms include photophobia, ocular irritation or pain, blurred vision, redness, mutton-fat keratic precipitates, posterior synechiae, and sometimes hypopyon. Intraocular pressure may be elevated due to blockage of the trabecular meshwork by inflammatory cells or lens material.


Classification level: Disorder
  • Synonym(s):
    • Endophthalmitis phacoanaphylactica
    • Lens-induced endophthalmitis
    • Lens-induced iridocyclitis
    • Lens-induced uveitis
    • Phacoallergic endophthalmitis
    • Phacoantigenic endophthalmitis
    • Phako-anaphylactic endophthalmitis
  • Prevalence: Unknown
  • Inheritance: Not applicable 
  • Age of onset: Adult
  • ICD-10: H20.2
  • ICD-11: 9A96.Y
  • OMIM: -
  • UMLS: C0152137  C0339320
  • MeSH: -
  • GARD: -
  • MedDRA: -
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