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Hallux varus-preaxial polysyndactyly syndrome

Disease definition

Hallux varus-preaxial polysyndactyly syndrome is a rare, genetic, congenital limb malformation disorder characterized by bilateral medial displacement of the hallux and preaxial polysyndactyly of the first toes. Radiographs show broad, shortened, misshapen first metatarsals and may associate incomplete or complete duplication of proximal phalanges and duplication or triplication of distal phalanges. There have been no further descriptions in the literature since 1980.


Classification level: Disorder
  • Synonym(s):
    • Kleiner-Holmes syndrome
  • Prevalence: <1 / 1 000 000
  • Inheritance: -
  • Age of onset: Neonatal
  • ICD-10: Q74.2
  • OMIM: 234280
  • UMLS: C1856197
  • MeSH: -
  • GARD: 3118
  • MedDRA: -
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