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Atypical hemolytic uremic syndrome

Disease definition

A rare, genetic thrombotic microangiopathy due to dysregulation of the alternative complement pathway and characterized by the triad of hemolytic anemia, thrombocytopenia, and acute renal dysfunction.


Classification level: Disorder
  • Synonym(s):
    • Atypical HUS
    • aHUS
  • Prevalence: 1-9 / 100 000
  • Inheritance: Autosomal dominant or Autosomal recessive or Not applicable 
  • Age of onset: All ages
  • ICD-10: D59.3
  • OMIM: 235400  609814  612922  612923  612924  612925  612926  615008
  • UMLS: C2931788
  • MeSH: C538266
  • GARD: 8702
  • MedDRA: -

Detailed information

Article for general public


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