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Metaplastic carcinoma of the breast

Disease definition

Metaplastic carcinoma of the breast is a rare, aggressive subtype of invasive breast carcinoma characterized by rapid growth, relatively large tumor size and a tendency to metastasize to distant organs, particularly the lungs, with relatively less frequent involvement of the axillary lymph nodes. Histologically, the tumor shows high-grade cellularity and heterologous differentiation, including chondroid, osseous, pleomorphic/sarcomatoid, spindled, and squamous elements. Patients usually present with a fast-growing, large, well-circumscribed, mobile lump in the breast, which can become painful and involve the chest wall and the skin, leading to ulceration.


Classification level: Disorder
  • Synonym(s): -
  • Prevalence: -
  • Inheritance: -
  • Age of onset: Adult
  • ICD-10: C50.0  C50.1  C50.2  C50.3  C50.4  C50.5  C50.6  C50.8
  • OMIM: -
  • UMLS: C1334708
  • MeSH: -
  • GARD: 10804
  • MedDRA: -

Detailed information

Article for general public

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