Orphanet: Ankylosing vertebral hyperostosis with tylosis

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Ankylosing vertebral hyperostosis with tylosis

Disease definition

A rare dysostosis with predominant vertebral involvement characterized by paraspinal ligament ossification (most pronounced in the lower thoracic region), osteophytosis, marginal sacroiliac joint sclerosis, and punctate hyperkeratosis on the soles and palms. Patients may be asymptomatic or present mild to moderate back pain. There have been no further descriptions in the literature since 1969.


Classification level: Disorder
  • Synonym(s): -
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal dominant 
  • Age of onset: Adult
  • ICD-10: M48.1
  • OMIM: 106400
  • UMLS: -
  • MeSH: -
  • GARD: 842
  • MedDRA: -
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