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Familial partial lipodystrophy, Dunnigan type

Disease definition

A rare, genetic lipodystrophy characterized by a loss of subcutaneous adipose tissue from the trunk, buttocks and limbs; fat accumulation in the neck, face, axillary and pelvic regions; muscular hypertrophy; and usually associated with metabolic complications such as insulin resistance, diabetes mellitus, dyslipidemia and liver steatosis.


Classification level: Disorder
  • Synonym(s):
    • Dunnigan syndrome
    • FPLD2
    • Familial partial lipodystrophy type 2
  • Prevalence: Unknown
  • Inheritance: Autosomal dominant 
  • Age of onset: Elderly, Adolescent, Adult, Childhood
  • ICD-10: E88.1
  • ICD-11: 5A44
  • OMIM: 151660
  • UMLS: C1720860
  • MeSH: -
  • GARD: 3126
  • MedDRA: -

Detailed information


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