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HELLP syndrome

Disease definition

A rare hemorrhagic disorder due to an acquired platelet anomaly characterized by hemolysis, elevated liver enzymes and thrombocytopenia that affects pregnant or post-partum women, and is frequently associated with severe preeclampsia. Symptoms are variable, typically including right upper quadrant or epigastric abdominal pain, nausea, vomiting, excessive weight gain, generalized edema, hypertension, general malaise, right shoulder pain, backache, and/or headache. Hepatic hemorrhage and rupture, renal failure, and pulmonary edema can result in maternal and/or fetal death.


Classification level: Disorder
  • Synonym(s):
    • Hemolysis, elevated liver enzymes, low platelets in pregnancy
    • Hemolysis-elevated liver enzymes-low platelets syndrome
  • Prevalence: Unknown
  • Inheritance: Multigenic/multifactorial 
  • Age of onset: Adult
  • ICD-10: O14.2
  • ICD-11: JA24.2
  • OMIM: -
  • UMLS: C0162739
  • MeSH: D017359
  • GARD: 8528
  • MedDRA: 10049058
The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.