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Juvenile primary lateral sclerosis

Disease definition

A very rare motor neuron disease characterized by progressive upper motor neuron dysfunction leading to loss of the ability to walk with wheelchair dependence, and subsequently, loss of motor speech production.

ORPHA:247604

Classification level: Disorder
  • Synonym(s):
    • JPLS
    • Juvenile PLS
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal recessive 
  • Age of onset: Childhood
  • ICD-10: G12.2
  • OMIM: 606353
  • UMLS: C1853396
  • MeSH: C536416
  • GARD: 4485
  • MedDRA: -

Detailed information

Professionals

The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.