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Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations

Disease definition

Retinal vasculopathy and cerebral leukodystrophy (RVCL) is an inherited group of small vessel diseases comprised of cerebroretinal vasculopathy (CRV), hereditary vascular retinopathy (HRV) and hereditary endotheliopathy with retinopathy, nephropathy and stroke (HERNS; see these terms); all exhibiting progressive visual impairment as well as variable cerebral dysfunction.


  • Synonym(s):
    • RVCL
    • RVCL-S
    • Retinal vasculopathy and cerebral leukoencephalopathy
  • Prevalence: Unknown
  • Inheritance: Autosomal dominant 
  • Age of onset: -
  • ICD-10: -
  • OMIM: 192315
  • UMLS: C1860518
  • MeSH: -
  • GARD: 1217
  • MedDRA: -

Additional information

Specialised Social Services

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