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Myalgia-eosinophilia syndrome associated with tryptophan

Disease definition

Myalgia-eosinophilia syndrome associated with tryptophan is a rare systemic disease characterized by severe myalgia and peripheral eosinophilia associated with tryptophan dietary supplementation. The symptoms do not subside after tryptophan discontinuation. Clinical presentation includes muscle tenderness and cramps, fatigue, weakness, paresthesia, peripheral edema, arthralgia, dyspnea, skin rash, dry mouth, and development of scleroderma-like skin abnormalities.

ORPHA:2582

Classification level: Disorder
  • Synonym(s): -
  • Prevalence: Unknown
  • Inheritance: Not applicable 
  • Age of onset: All ages
  • ICD-10: M35.8
  • ICD-11: 4A43.Y 
  • OMIM: -
  • UMLS: C1275050
  • MeSH: D016603
  • GARD: -
  • MedDRA: 10014952

  A summary on this disease is available in Español (2018) Italiano (2018) Nederlands (2018)

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The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.