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Myalgia-eosinophilia syndrome associated with tryptophan

Disease definition

Myalgia-eosinophilia syndrome associated with tryptophan is a rare systemic disease characterized by severe myalgia and peripheral eosinophilia associated with tryptophan dietary supplementation. The symptoms do not subside after tryptophan discontinuation. Clinical presentation includes muscle tenderness and cramps, fatigue, weakness, paresthesia, peripheral edema, arthralgia, dyspnea, skin rash, dry mouth, and development of scleroderma-like skin abnormalities.


Classification level: Disorder
  • Synonym(s): -
  • Prevalence: Unknown
  • Inheritance: Not applicable 
  • Age of onset: All ages
  • ICD-10: M35.8
  • ICD-11: 4A43.Y 
  • OMIM: -
  • UMLS: C1275050
  • MeSH: D016603
  • GARD: -
  • MedDRA: 10014952
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