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Septopreoptic holoprosencephaly
Disease definition
A rare subtype of holoprosencephaly characterized by midline fusion limited to the septal and/or preoptic regions of the telencephalon without a significant frontal neocortical fusion. Midline craniofacial malformations are generally mild and include solitary median maxillary incisor and pyriform sinus stenosis. Other reported manifestations include language delay, learning difficulties, and behavioral disorders. Imaging reveals abnormal fornix, absent or hypoplasic anterior corpus callosum, and unpaired anterior cerebral artery.
ORPHA:280195
Classification level: Subtype of disorderA summary on this disease is available in Español (2020) Français (2020) Nederlands (2020) Deutsch (2011) Italiano (2011) Português (2011) Polski (2011, pdf)
Detailed information
Genetic Testing
- Guidance for genetic testing
- English (2010) - Eur J Hum Genet
- Français (2015, pdf) - ANPGM


Additional information
Further information on this disease
Patient-centred resources for this disease
Research activities on this disease
Specialised Social Services
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