x

Search for a rare disease

* (*) mandatory field

Other search option(s)

Suggest an update

(*) Required fields.

Attention

Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed.

Captcha image

POEMS syndrome

Disease definition

POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels.

ORPHA:2905

  • Synonym(s):
    • Crow-Fukase syndrome
    • Osteosclerotic myeloma
    • PEP syndrome
    • Polyneuropathy-endocrinopathy-plasma cell dyscrasia syndrome
    • Takatsuki syndrome
  • Prevalence: Unknown
  • Inheritance: Unknown 
  • Age of onset: Adult, Elderly
  • ICD-10: D47.7
  • OMIM: -
  • UMLS: C0085404  C1510415
  • MeSH: D016878
  • GARD: 7411
  • MedDRA: 10053869

Detailed information

Professionals

The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.