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Familial male-limited precocious puberty

Disease definition

Familial male limited precocious puberty (FMPP) is a gonadotropin-independent familial form of male-limited precocious puberty, generally presenting between 2-5 years of age as accelerated growth, early development of secondary sexual characteristics and reduced adult height.


Classification level: Disorder
  • Synonym(s):
    • FMPP
    • Familial gonadotropin-independent male-limited sexual precocity
    • Male-limited precocious puberty
    • Testotoxicosis
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal dominant 
  • Age of onset: Childhood
  • ICD-10: E30.1
  • OMIM: 176410
  • UMLS: C0342549  C1504412
  • MeSH: C536961
  • GARD: 4475
  • MedDRA: 10063654  10063656

Detailed information


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