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T-cell/histiocyte rich large B cell lymphoma

Disease definition

T-cell/histiocyte rich large B cell lymphoma (THRLBCL) is a rare variant of diffuse large B-cell lymphoma (DLBCL; see this term), mainly affecting middle-aged men and often not being discovered until an advanced disease stage, with involvement of the spleen, liver and bone marrow occurring at a greater frequency than in DLBCL. It is often difficult to diagnose due to its similarity with other lymphoid diseases such as classic Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma (see these terms) and has an aggressive clinical course.


Classification level: Disorder
  • Synonym(s):
  • Prevalence: -
  • Inheritance: Multigenic/multifactorial or Not applicable 
  • Age of onset: Childhood, Adolescent, Adult, Elderly
  • ICD-10: C83.3
  • OMIM: -
  • UMLS: C1321547
  • MeSH: -
  • GARD: 12257
  • MedDRA: -

Detailed information


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