Orphanet: Satoyoshi syndrome

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Satoyoshi syndrome

Disease definition

Satoyoshi syndrome is a rare, multisystemic autoimmune disease mainly characterized by intermittent painful muscle spasms, alopecia (totalis or universalis in most cases) and long-lasting diarrhea that could lead to malnutrition, growth retardation, and amenorrhea. Secondary bone deformities and various endocrine anomalies may also be associated. Antinuclear antibodies are reported in many cases.


Classification level: Disorder
  • Synonym(s):
    • Komuragaeri disease
  • Prevalence: <1 / 1 000 000
  • Inheritance: Not applicable 
  • Age of onset: Childhood, Adolescent, Adult
  • ICD-10: M35.8
  • OMIM: 600705
  • UMLS: C1833454
  • MeSH: C536616
  • GARD: 160
  • MedDRA: 10070579
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