Search for a rare disease

* (*) mandatory field

Other search option(s)

Suggest an update

(*) Required fields.


Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed.

Captcha image

Autoimmune polyendocrinopathy type 2

Disease definition

A rare, endocrine disease characterized by autoimmune Addison disease associated with autoimmune thyroid disease or type I diabetes mellitus, or both, and without chronic candidiasis. Additional endocrine (hypogonadism, hypoparathyroidism) and non-endocrine diseases (vitiligo, autoimmune hepatitis, autoimmune gastritis, pernicious anemia, and myasthenia gravies) may be present.


Classification level: Disorder
  • Synonym(s):
    • APS type 2
    • APS2
    • Autoimmune polyendocrine syndrome type 2
    • Autoimmune polyglandular syndrome type 2
    • Autoimmune thyroid disease and/or type 1 diabetes-Addison disease syndrome
    • Schmidt syndrome
  • Prevalence: Unknown
  • Inheritance: -
  • Age of onset: Adult
  • ICD-10: E31.0
  • OMIM: 269200
  • UMLS: C0085860
  • MeSH: -
  • GARD: 7611
  • MedDRA: -
The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.