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MAGIC syndrome

Disease definition

A rare autoinflammatory syndrome characterized by the presence of features of relapsing polychondritis and Behçet's disease in the same individual. This includes cartilage inflammation of the ears, nose, throat, and rib cage, as well as recurrent oral and genital ulcers, respectively. Patients may also present ocular involvement (in particular anterior uveitis or scleritis), arthritis, fever, colitis, thrombophlebitis, central nervous system vasculitis, or, in rare cases, arterial aneurysms. Symptoms of polychondritis occur secondary to those of Behçet's disease in the vast majority of cases.


Classification level: Disorder
  • Synonym(s):
    • Mouth and genital ulcers-inflamed cartilage syndrome
  • Prevalence: <1 / 1 000 000
  • Inheritance: -
  • Age of onset: Childhood, Adolescent, Adult
  • ICD-10: D89.8
  • OMIM: -
  • UMLS: C0406568
  • MeSH: -
  • GARD: -
  • MedDRA: 10078132

Detailed information


ERN produced/endorsed by ERN(s)   FSMR produced/endorsed by FSMR(s)
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