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C3 glomerulopathy

Disease definition

A form of primary membranoproliferative glomerulonephritis characterized by the presence in renal biopsy samples of a glomerulonephritis with sole (or at least dominant) glomerular immunofluorescence staining for C3. Non-specific alterations or proliferative patterns with C3-dominant glomerular staining are also possible. Based upon electron microscopic findings, C3 glomerulopathy (C3G) may be further classified as C3 glomerulonephritis (C3GN) or Dense deposit disease (DDD).

ORPHA:329918

Classification level: Subtype of disorder
  • Synonym(s):
    • Non-Ig-mediated MPGN
    • Non-Ig-mediated membranoproliferative glomerulonephritis
    • Non-immunoglobulin-mediated MPGN
    • Non-immunoglobulin-mediated membranoproliferative glomerulonephritis
  • Prevalence: -
  • Inheritance: Multigenic/multifactorial 
  • Age of onset: All ages
  • ICD-10: N03.5
  • OMIM: 609814  614809
  • UMLS: -
  • MeSH: -
  • GARD: -
  • MedDRA: -

Detailed information

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