x

Search for a rare disease

* (*) mandatory field

Other search option(s)

Suggest an update

(*) Required fields.

Attention

Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed.

Captcha image

Primary lateral sclerosis

Disease definition

Primary lateral sclerosis (PLS) is an idiopathic non-familial motor neuron disease characterized by slowly progressive upper motor neuron dysfunction leading to spasticity, mild weakness in voluntary muscle movement, hyperreflexia, and loss of motor speech production.

ORPHA:35689

  • Synonym(s):
    • Adult-onset PLS
    • Adult-onset primary lateral sclerosis
    • PLS
  • Prevalence: 1-9 / 100 000
  • Inheritance: Not applicable or Autosomal recessive or Autosomal dominant 
  • Age of onset: Elderly, Adult
  • ICD-10: G12.2
  • OMIM: 611637
  • UMLS: C0154682  C1968845
  • MeSH: -
  • GARD: 10684
  • MedDRA: 10036704

Additional information

Further information on this disease

Health care resources for this disease

Research activities on this disease

Specialised Social Services

The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.