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Primary lateral sclerosis
Disease definition
Primary lateral sclerosis (PLS) is an idiopathic non-familial motor neuron disease characterized by slowly progressive upper motor neuron dysfunction leading to spasticity, mild weakness in voluntary muscle movement, hyperreflexia, and loss of motor speech production.
ORPHA:35689
Classification level: Disorder- Synonym(s):
- Adult-onset PLS
- Adult-onset primary lateral sclerosis
- PLS
- Prevalence: 1-9 / 100 000
- Inheritance: Not applicable or Autosomal recessive or Autosomal dominant
- Age of onset: Elderly, Adult
- ICD-10: G12.2
- ICD-11: 8B60.4
- OMIM: 611637
- UMLS: C0154682 C1968845
- MeSH: -
- GARD: 10684
- MedDRA: 10036704
Additional information
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