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Primary lateral sclerosis
Disease definition
Primary lateral sclerosis (PLS) is an idiopathic non-familial motor neuron disease characterized by slowly progressive upper motor neuron dysfunction leading to spasticity, mild weakness in voluntary muscle movement, hyperreflexia, and loss of motor speech production.
ORPHA:35689
Classification level: DisorderA summary on this disease is available in Español (2015) Italiano (2015) Nederlands (2015) Deutsch (2004) Français (2004) Português (2004)
Detailed information
Clinical Outcome Assessment (COA)
- Patient-Centered Outcome Measures (PCOMs)
- English (2023) - PROQOLIDTM


Additional information
Further information on this disease
Patient-centred resources for this disease
Research activities on this disease
Specialised Social Services
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