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Giant cell tumor of bone

Disease definition

A rare bone sarcoma characterized by a usually benign space-occupying lesion, which is nevertheless locally aggressive and massively damaging to surrounding bone tissue. The tumor is composed of giant multinucleated cells (osteoclast-like cells), mononuclear macrophages, and mononuclear stromal cells which secrete pro-myeloid and pro-osteoclastic factors. Metastasis and malignant transformation are rare, but the recurrence rate is high.


Classification level: Disorder
  • Synonym(s):
    • GCT of bone
    • Osteoclastoma
  • Prevalence: Unknown
  • Inheritance: Not applicable 
  • Age of onset: Adult
  • ICD-10: D48.0
  • ICD-11: 2F7B  2F9B  XH0492  XH4TC2
  • OMIM: -
  • UMLS: C0206638
  • MeSH: -
  • GARD: -
  • MedDRA: -

Detailed information


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