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Giant cell tumor of bone
Disease definition
A rare bone sarcoma characterized by a usually benign space-occupying lesion, which is nevertheless locally aggressive and massively damaging to surrounding bone tissue. The tumor is composed of giant multinucleated cells (osteoclast-like cells), mononuclear macrophages, and mononuclear stromal cells which secrete pro-myeloid and pro-osteoclastic factors. Metastasis and malignant transformation are rare, but the recurrence rate is high.
ORPHA:363976
Classification level: DisorderDetailed information
Professionals
- Review article
- Deutsch (2011)
- Clinical practice guidelines
- English (2018)
Additional information
Further information on this disease
Patient-centred resources for this disease
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Specialised Social Services
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