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Huriez syndrome

Disease definition

A rare genetic skin disease characterized by the triad of congenital scleroatrophy predominantly of the hands with sclerodactyly, palmoplantar keratoderma, and nail changes (consisting of hypoplasia, ridging, clubbing, and white discoloration). Additional features include palmar hypohidrosis and a high susceptibility to early-onset squamous cell carcinoma of affected skin areas.


Classification level: Disorder
  • Synonym(s):
    • Palmoplantar hyperkeratosis-sclerodactyly syndrome
    • Palmoplantar keratoderma-sclerodactyly syndrome
    • Scleroatrophic syndrome
    • Sclerotylosis
  • Prevalence: -
  • Inheritance: Autosomal dominant 
  • Age of onset: Neonatal, Infancy
  • ICD-10: Q82.8
  • OMIM: 181600
  • UMLS: C0406767
  • MeSH: -
  • GARD: 8517
  • MedDRA: -
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