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Autosomal spastic paraplegia type 58

Disease definition

A rare, complex subtype of hereditary spastic paraplegia characterized by variable onset of slowly progressive lower limb spasticity and weakness and prominent cerebellar ataxia, associated with gait disturbances, dysarthria, increased deep tendon reflexes and extensor plantar responses. Additional features may include involuntary movements (i.e. clonus, tremor, fasciculations, chorea), decreased vibration sense, oculomotor abnormalities (e.g. nystagmus) and distal amyotrophy in the upper and lower limbs.


Classification level: Disorder
  • Synonym(s):
    • Autosomal spastic ataxia type 2
    • SPAX2
    • SPG58
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal dominant or Autosomal recessive 
  • Age of onset: Childhood, Adolescent, Adult, Elderly, Infancy
  • ICD-10: G11.4
  • OMIM: 611302
  • UMLS: C1969796
  • MeSH: -
  • GARD: -
  • MedDRA: -

Detailed information

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Disease review articles


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