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Hyperkeratosis lenticularis perstans

Disease definition

A rare skin disease characterized by usually asymptomatic, hyperkeratotic, reddish-brown papules primarily located on the lower extremities. Histological examination shows lamellar hyperkeratosis with abrupt peripheral basket-weave orthokeratosis, irregular acanthosis, and underlying lichenoid lymphocytic infiltrate. The condition may be sporadic or familial.

ORPHA:409

Classification level: Disorder
  • Synonym(s):
    • Flegel disease
  • Prevalence: Unknown
  • Inheritance: Autosomal dominant or Not applicable 
  • Age of onset: Adult
  • ICD-10: -
  • OMIM: 144150
  • UMLS: C0263420
  • MeSH: C538377
  • GARD: 2824
  • MedDRA: 10071311

Additional information

Further information on this disease

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The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.