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Primary central nervous system lymphoma

Disease definition

Primary central nervous system lymphoma (PCNSL) is a rare nervous system tumor, predominantly due to diffuse large B-cell lymphoma, that involves brain, leptomeninges, eyes, or rarely spinal cord, in the absence of systemic diffusion at the time of diagnosis. It is characterized by a solitary tumor that, depending on its location, can lead to a variety of symptoms such as headache, nausea, vomiting (and other signs of raised intracranial pressure), focal neurologic deficits, neuropsychiatric and ocular symptoms, seizures and personality changes.


Classification level: Disorder
  • Synonym(s):
    • PCNSL
    • Primary CNS lymphoma
    • Primary brain lymphoma
  • Prevalence: -
  • Inheritance: Not applicable 
  • Age of onset: -
  • ICD-10: C83.3
  • OMIM: -
  • UMLS: C0240803  C0280803
  • MeSH: -
  • GARD: 9318
  • MedDRA: 10036685

Detailed information


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