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Exercise-induced malignant hyperthermia
Disease definition
A rare disease with malignant hyperthermia characterized by exercise-induced life-threatening hyperthermia with a body temperature over 40°C and signs of encephalopathy ranging from confusion to convulsions or coma. Incidence increases with rising ambient temperature and relative humidity. Manifestations may include rhabdomyolysis (presenting with myalgia, muscle weakness, and myoglobinuria), tachycardia, and in severe cases multiorgan failure.
ORPHA:466650
Classification level: Disorder- Synonym(s):
- Exertional heat stroke
- Prevalence: Unknown
- Inheritance: Multigenic/multifactorial
- Age of onset: All ages
- ICD-10: T88.3
- ICD-11: NF06.0
- OMIM: -
- UMLS: C4544037
- MeSH: -
- GARD: -
- MedDRA: -
A summary on this disease is available in Deutsch (2020) Español (2020) Français (2020) Nederlands (2020)
Detailed information
Guidelines
- Emergency guidelines
- Français (2017, pdf) - Orphanet Urgences
- Español (2018, pdf) - Orphanet Urgences
Disease review articles
- Review article
- English (2015) - Orphanet J Rare Dis


Additional information
Further information on this disease
Patient-centred resources for this disease
Research activities on this disease
Specialised Social Services
The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.