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Exercise-induced malignant hyperthermia

Disease definition

A rare disease with malignant hyperthermia characterized by exercise-induced life-threatening hyperthermia with a body temperature over 40°C and signs of encephalopathy ranging from confusion to convulsions or coma. Incidence increases with rising ambient temperature and relative humidity. Manifestations may include rhabdomyolysis (presenting with myalgia, muscle weakness, and myoglobinuria), tachycardia, and in severe cases multiorgan failure.


Classification level: Disorder
  • Synonym(s):
    • Exertional heat stroke
  • Prevalence: Unknown
  • Inheritance: Multigenic/multifactorial 
  • Age of onset: All ages
  • ICD-10: T88.3
  • ICD-11: NF06.0
  • OMIM: -
  • UMLS: C4544037
  • MeSH: -
  • GARD: -
  • MedDRA: -

Detailed information


Disease review articles

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