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Cat-scratch disease

Disease definition

Cat-scratch disease is a rare infectious disease, caused by the Gram-negative bacteria Bartonella henselae, that is transmitted to humans via a scratch or bite of an infected cat and that has a variable clinical presentation but that usually manifests with an erythematous papule at the site of inoculation followed by chronic regional lymphadenopathy. Clinical course is usually self-limiting but disseminated illness with high fever, hepatosplenomegaly, granulomatous osteolytic lesions, encephalitis, retinitis, and atypical pneumonia can also occur. Cat-scratch disease can atypically present as parinaud oculoglandular syndrome (unilateral conjunctivitis and preauricular lymphadenopathy).

ORPHA:50839

Classification level: Disorder
  • Synonym(s):
    • Bartonellosis due to Bartonella henselae infection
  • Prevalence: 1-9 / 100 000
  • Inheritance: Not applicable 
  • Age of onset: All ages
  • ICD-10: A28.1
  • OMIM: -
  • UMLS: C0007361  C0238909
  • MeSH: D002372
  • GARD: 27
  • MedDRA: 10007729
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