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Acute monoblastic/monocytic leukemia

Disease definition

A form of acute myeloid leukemia that is either comprised of more than 80% of monoblasts or 30-80% monoblasts with (pro)monocytic differentiation. It presents with asthenia, pallor, fever, and dizziness. Specific features include hyperleukocytosis, propensity for extramedullary infiltrates, coagulation abnormalities including disseminated intravascular coagulation and neurological disorders. Leukemia cutis and gingival infiltration can also be seen. A characteristic translocation observed is t(9;11).

ORPHA:514

Classification level: Disorder
  • Synonym(s):
    • AML M5
    • Acute monoblastic or monocytic leukemia
  • Prevalence: 1-9 / 1 000 000
  • Inheritance: Not applicable 
  • Age of onset: Childhood
  • ICD-10: C92.7
  • ICD-11: 2A60.34
  • OMIM: -
  • UMLS: C3831784
  • MeSH: D007948
  • GARD: 525
  • MedDRA: -

  A summary on this disease is available in Español (2015) Italiano (2015) Nederlands (2015) Deutsch (2004) Français (2004) Português (2004) Polski ()

Detailed information

General public

Disease review articles

Clinical Outcome Assessment (COA)

  • Patient-Centered Outcome Measures (PCOMs)
  • English (2023) - PROQOLIDTM
ERN produced/endorsed by ERN(s)   FSMR produced/endorsed by FSMR(s)

Additional information

Further information on this disease

Patient-centred resources for this disease

Research activities on this disease

Specialised Social Services

The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.