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CAR T cell therapy-associated cytokine release syndrome

Disease definition

A rare systemic condition affecting patients undergoing chimeric antigen receptor (CAR) T-cell therapy and characterized by a systemic inflammatory response due to massive activation of leukocytes with subsequent cytokine release. It can present with a variety of signs and symptoms ranging from mild, flu-like symptoms (such as fever, fatigue, headache, rash, arthralgia, and myalgia) to severe life-threatening manifestations including vascular leakage, disseminated intravascular coagulation, shock, and multiple organ failure. Respiratory manifestations are common and range from cough and tachypnea to acute respiratory distress syndrome (ARDS).


Classification level: Disorder
  • Synonym(s):
    • CAR T cell therapy-associated CRS
    • Chimeric antigen receptor-T cell therapy-associated cytokine release syndrome
  • Prevalence: Unknown
  • Inheritance: -
  • Age of onset: Adult
  • ICD-10: D89.8
  • OMIM: -
  • UMLS: -
  • MeSH: -
  • GARD: -
  • MedDRA: -
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