Orphanet: Congenital membranous nephropathy due to fetomaternal anti neutral endopeptidase alloimmunization

Search for a rare disease

* (*) mandatory field

Other search option(s)

Suggest an update

(*) Required fields.


Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed.

Orphanet doesn't provide personalised answers. To get in touch with the Orphanet team, please contact

Information provided in your contribution (including your email address) will be stocked in .CSV files that will be sent as an email to Orphanet's teams. These emails might be conserved in the teams' mailboxes, in our backoffice servers but will not be registered in our databases (for more information see our section General Data Protection Regulation and data privacy (GDPR) and Confidentiality).

Captcha image

Congenital membranous nephropathy due to fetomaternal anti-neutral endopeptidase alloimmunization

Disease definition

A rare, congenital glomerular disease due to maternal anti-neutral endopeptidase (NEP) alloimmunization characterized by severe renal failure and nephrotic syndrome at birth, which rapidly improves in the first weeks of life.


Classification level: Disorder
  • Synonym(s):
    • Alloimmune neonatal renal disease
    • FMAIG
    • Fetomaternal alloimmunization with antenatal glomerulopathies
    • Neonatal glomerulopathy due to neprilysin alloimmunization
    • Neonatal membranous glomerulopathy with maternal NEP deficiency
    • Neonatal membranous glomerulopathy with maternal neutral endopeptidase deficiency
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal recessive 
  • Age of onset: Neonatal, Antenatal
  • ICD-10: P96.0
  • OMIM: -
  • UMLS: -
  • MeSH: -
  • GARD: -
  • MedDRA: -

Detailed information


ERN : produced/endorsed by ERN(s)
FSMR : produced/endorsed by FSMR(s)
The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.