Orphanet: Liposarcoma

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Liposarcoma

Disease definition

Liposarcoma (LS), a type of soft tissue sarcoma, describes a group of lipomatous tumors of varying severity ranging from slow-growing to aggressive and metastatic. Liposarcomas are most often located in the lower extremities or retroperitoneum, but they can also occur in the upper extremities, neck, peritoneal cavity, spermatic cord, breast, vulva and axilla.

ORPHA:69078

Classification level: Disorder

Synonym(s): -
Prevalence: Unknown
Inheritance: Unknown
Age of onset: All ages
ICD-10: C49.9
ICD-11: 2B59 2B59.0 2B59.1 2B59.2 2B59.Y
OMIM: 613488
UMLS: C0023827
MeSH: D008080
GARD: 6913
MedDRA: 10024627

Summary

Epidemiology

Liposarcomas account for approximately 15-20% of all soft tissue sarcomas. The incidence is approximately 1 per 100, 000 persons/years.

Clinical description

They can affect all age groups but are most frequently seen in middle-aged and older adults. Liposarcomas are classified into 4 biological groups (encompassing five histological subtypes): well-differentiated (WDLS), dedifferentiated (DDLS), myxoid /round cell (MRCLS) and pleomorphic (PLS) (see these terms).

Etiology

The etiology is unknown but many chromosomal aberrations are found in liposarcomas.

Prognosis

The prognosis is dependent on the specific subtype, size, stage and location of the disease.

Expert reviewer(s): Dr Samuel SINGER - Last update: January 2013

A summary on this disease is available in Deutsch (2013) Español (2013) Français (2013) Italiano (2013) Nederlands (2013) Polski (2013, pdf)

Detailed information

General public

Article for general public
English (2017) - PDQ Cancer Inf Sum

Guidelines

Clinical practice guidelines
Deutsch (2011) - AWMF
English (2018) - Ann Oncol
English (2021) - Ann Oncol

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produced/endorsed by FSMR(s)

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